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KMID : 0359919920110020180
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Korean Journal of Nephrology
1992 Volume.11 No. 2 p.180 ~ p.186
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A Case of Seizure Associated rHuEPO Thrapy for Hemosiderosis on a Chronic Renal Failure Patient
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Abstract
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Iron overload from repeated transfusions of RBCs in long-term hemodialysis patients is a problem of increasing clinical significance. Use of recombinant human erythropoietin (rHuEPO) and phlebotomy is an effective and safe method of reducing iron
overload in dialysis patient.
We report on a 54-year-old woman using hemodialy sis who had attacks of grand mal seizure during rHuE PO treatment.
She had a diagnosis of hemosiderosis with high serum ferritin (above 6000 ng/dl) from the study of abdominal CT scanning, liver and bone marrow biopsies 2 months before. So the rHuEPO (50 units/Kg) was given intravenously three times weekly
immediately
after dialysis for 8 weeks prior to seizure attacks.
On admission after fits she was post-ictal with no focal neurological sign, her blood pressure was 230/110 mmHg and her hemoglobin concentration was 10.3g/gl. Results of biochemical tests were stable, and those of brain CT scan, cerebrospinal
fluid
pressure and osmolality were normal.
Seizure subsided after repeated phlebotomy and aggressive control of high blood pressure, rHuEPO was temporarily stopped and 2 weeks later was resummed (25 units/Kg twice a week) with no more fit.
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